Enzyme-linked Immunosorbent Assay:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
Staining:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
Real-time Polymerase Chain Reaction:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
SYBR Green Assay:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
Magnetic Beads:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
Antibody Labeling:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
AST Assay:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
Single Cell:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
RNA Sequencing:Article Title: Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CA-5f MCE HY-112698 ATG7-IN-2 MCE HY-146130 DC-LC3in-D5 MCE HY-141882 Bafilomycin A1 MCE HY-100558 Chloroquine MCE HY-17589A Pitstop 2 MCE HY-115604 Methyl-β-cyclodextrin MCE HY-101461 β-amyloid (1-42), Human MCE HY-P1363A LRP-1 cluster II protein, Human (HEK293, His) MCE HY-P702520 LRP-1 cluster II protein, Human (HEK293, Fc) MCE HY-P704765 LRP-1 cluster III protein, Human (HEK293, Fc) MCE HY-P704766 LRP-1 cluster IV protein, Human (HEK293, Fc) MCE HY-P704767 ASGR1/ASGPR1 Protein, Human (HEK293, His) MCE HY-P7610 ASGR2 Protein, Human (HEK293, His) MCE HY-P76736 LRPAP1 protein, Human MCE HY-P76478A LRPAP1 protein, Mouse MCE HY-P76479A Critical commercial assays Thio-S Sigma 1326-12-1 Huma Aβ 1-42 Quantikine ELISA Kit R&D Systems DAB142 Huma Aβ 1-40 Quantikine ELISA Kit R&D Systems DAB140B Iron Stain Kit (Prussian Blue Stain) Abcam ab150674 Mouse CD11b microbeads MiltenyiBiotec 130-093-634 Myelin Removal Beads II Miltenyi Biotec 130-096-433 Hito Golgi-Cox OptimStainTM Kit HiTO Biotec HTKNS1125 HieffTM qPCR SYBR Green Master Mix YEASEN 11201ES08 PierceTM Streptavidin Magnetic Beads Thermo Fisher 88816 PierceTM Protein A/G Magnetic Beads Thermo Fisher 88802 pHrodoTM Antibody Labeling Kit Thermo Fisher P36014 PierceTM Biotinylated Protein Interaction Pull-Down Kit Thermo Fisher 21115 Mouse TNF alpha ELISA Kit Invitrogen BMS607-3 Mouse IL-6 ELISA Kit Invitrogen KMC0061 Dynabeads Protein G Invitrogen 10003D Lipofectamine LTX and PLUS reagent Invitrogen 15338100 Mouse ALT/GPT (Alanine Aminotransferase) ELISA Kit Jiangmei Biotechnology M-02543M2 Mouse AST (Aspartate Aminotransferase) ELISA Kit Jiangmei Biotechnology JM-03113M2 Mouse GGT (Gamma-Glutamyl Transferase) ELISA Kit Jiangmei Biotechnology JM-11634M2 Mouse total protein TP ELISA Kit Saipei Biotechnology SP14882 Deposited data Single-cell RNA sequencing data This paper GSA: CRA018421 Experimental models: Cell lines HEK293T ATCC CRL-1573 HeLa ATCC CRM-CCL-2 HepG2 ATCC HB-8065 Huh-7 Procell CL-0120 AML12 Procell CL-0602 U251 Procell CL-0237 SH-SY5Y Procell CL-0208 (Continued on next page) ll OPEN ACCESS Cell 189, 1–19.e1–e10, April 2, 2026 e2 Please cite this article in press as: Teng et al., Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs, Cell (2026), https:// doi.org/10.1016/j.cell.2026.01.034 Article .. 5×FAD transgenic mice (B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/Mmjax, 34840-JAX) and APP/PS1 transgenic mice (B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) were purchased from the Jackson Laboratory.
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